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KMID : 0377519880130020237
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Chung-Ang Journal of Medicine
1988 Volume.13 No. 2 p.237 ~ p.248
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On the Origin of the Specific IgG Antibody in Cerebrospinal fluid of Neuroparagonimiasis and Neurosparganosis patients
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Hahn, Chong-Hie/한종희
Kim, Suk-Il/Kang, Shin-Yong/Cho, Seung-Yull/Park, Ae-Ja/김석일/강신영/조승열/박애자
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Abstract
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From July 1982 to January 1987, sera and CSF were collected from 12 neuroparagonimiasis and 15 neurosparganosis patients respectively. The contents of total protein, albumin and IgG were measured in sera and CSF. Specific IgG antibody levels in sera and CSF were examined by ELISA. From these data the relative con.tribu-tions of transudation, exudation and intracranial synthesis of IgG to total contents of IgG in CSF were calculated through the application of formula of Tourtellotte and Ma (1978). The relationship between intracranial synthesis of IgG and the levels of specific IgG antibody in CSF were assessed.. The results are summarized as follows:
1. In cases of neuroparagonimiasis, IgG levels in serum and contents of total protein, albumin and IgG in CSF were elevated significantly. The evidence of intracranial synthesis of IgG was re-cognized in 7 out of 12 patients. And intracranial synthesis of IgG was correlated with the positive reaction of specific antibody in CSF.
2. In neurosparganosis patients, total protein, albumin and IgG in CSF were either slightly elevated or in normal ranges. However, the evidence of intracranial synthesis of IgG was recognized in 6 of 15 patients. It was also correlated with positive reaction of specific IgG antibody in C-SF.
From the above results, it was strongly suggested that the specific IgG antibody in neuroparagonimiasis and neurosparganosis originate from intracranial synthesis, especially during their active infections.
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